Polycystin-1 Enhances Stemmness Potential of Umbilical Cord Blood-Derived Mesenchymal Stem Cells

Polycystic Kidney Disease (PKD) is a disorder that affects the kidneys and other organs, its major forms are encoded by polycystin-1 (PC1) polycystin-2 (PC2), as PKD1 PKD2. It located sandwiched inside outside cell membranes interacts with cells. This protein most active in kidney cells before birth, PC1 PC2 work together to help regulate proliferation, migration, interactions The molecular relationship function between cancer well known, such increased or decreased proliferation promoting suppressing migration depending on type specifically. However, stem has not been revealed. Therefore, this study, we investigated biological of umbilical cord blood-derived mesenchymal (UCB-MSC). Furthermore, assessed how it viability when expressed gene. In addition, confirmed an ex vivo artificial tooth model generated three-dimension printing technique ability differentiate into osteocytes improved according expression level stemness markers was expressed. study first report examine UCB-MSC. gene may be capable enhancing differentiation maintaining long-term for therapeutic use